![]() Does this product come in other product forms?įor a complete assortment of products by the manufacturer of this supplement, click on the link next to the item name at the top of the page. If you are unsure about the safety of this product for your pet, we recommend consulting with your veterinarian. My pet is allergic to certain ingredients, will this product be safe to use?įor a complete list of ingredients, click on the 'Nutritional Info' tab, next to the 'Description' tab, just under the product photos. If your pet has a medical condition and is taking other medication, we recommend consulting with your veterinarian to ensure that this supplement is safe to use. ![]() Is this supplement safe to use with the medication my pet is currently taking? Please refer to the Feeding Instructions tab and consult with your veterinarian for more information. It is recommended to give the suggested dosage based off your pet’s weight. How often should I give this supplement to my pet? Consult your veterinarian to determine the best vitamins and supplements for your furry friend. Like in humans, vitamins and supplements can help support your pet’s long-term health, regulating everything from digestion to muscle growth. Most commercial pet foods include baseline vitamins and nutrients, but some may not have the adequate amount to suit your pet’s exact health needs. Why should I include vitamins & supplements in my pet’s diet? In case of an accidental overdose, consult a veterinarian immediately. Keep out of reach of children and animals. Not for use within 48 hours of surgery/anesthesia. An examination from a veterinarian is recommended prior to using this product. Administer during or after the animal has eaten to reduce incidence of gastrointestinal upset. If lameness worsens, discontinue use and contact your veterinarian. Consult with your veterinarian before using this product in animals: with clotting disorders being treated with anticoagulant medications diabetes, or any metabolic disorder causing hyperglycemia history of urinary tract stones known allergies to shellfish may be a GI irritant. HAZARDS TO ANIMALS: Not for use in pregnant animals. This screen can facilitate developability risk assessment and mitigation strategies for antibody based therapeutics via rapid high throughput material-free screening.Large Breeds, All Breeds, Extra Small Breeds, Small Breeds, Medium Breeds, Giant Breeds An empirically derived equation that connects aggregation propensity and pI of the Fv region with high concentration viscosity of the whole mAb was developed.Īn Fv region-based qualitative screening profile was devised to flag mAb candidates whose development, as high concentration drug products, could prove challenging. Negative net charges on the Fv regions of two mAbs with poor viscosity behaviors facilitate attractive self-associations, causing them to diffuse slower than a well-behaved mAb with positive net charge on its Fv region. Net charge, ξ-potential and pI of Fv regions were found to correlate with viscosities of highly concentrated antibody solutions. Coarse-grained molecular simulations of two problematic mAbs were compared with that of a well behaved mAb. Sequence and structural features of the variable (Fv) regions were analyzed to understand viscosity behavior of the mAbs. Early identification of monoclonal antibody candidates whose development, as high concentration (≥100 mg/mL) drug products, could prove challenging, due to high viscosity, can help define strategies for candidate engineering and selection.Ĭoncentration dependent viscosities of 11 proprietary mAbs were measured.
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